Development of new inks to obtain controlled release solid pharmaceutical forms through 3D printing

Abstract

Ricobendazole (RBZ), a drug widely used in the treatment of parasitic infections, is a weak base and has extremely low solubility in environments whose pH is greater than 2, so stomach acid represents an effective environment for its dissolution and absorption. Furthermore, formulations based on lipid matrices (such as Gelucires G 43/01, G 50/13 and stearic acid, AS) could improve the bioavailability of RBZ. With the melt solidification 3D printing technique (MESO-PP), floating systems can be designed in aqueous media and the drug released in a controlled manner.