Synthesis and characterization of a film composed of micellar casein and 4-(butylamino)benzoic acid 2-(dimethylamino)ethyl ester monohydrochloride

Abstract

In the present study, it was proposed to synthesize a film that incorporates 4-(butylamino)benzoic acid 2-(dimethylamino)ethyl monohydrochloride as an active compound, since it is widely used in medicine for its anesthetic property. In the proposed formulations was used a natural polymer, casein, and in addition, compounds such as glycerol and potassium alginate were added in order to modify certain mechanical and physical properties. In this way, various experiments were carried out, varying the amounts of each component until the film reached the desired characteristics. The film F3 was acceptable, so it was subjected to a series of tests to characterize it. Among the tests carried out are the determination of thickness, moisture content, total soluble material and insoluble solid. The results obtained were optimal to study the possibility of its application as a local anesthetic in dentistry.